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TARGET HEART BIOTEC SRL
Via Ribes 5, c/o Bioindustry Park del Canavese - 10010 Colleretto Giacosa (TO),ITALY
Telephone: +39 0125 538874
Fax: +39 0125 538791
Contact: Prof. Guido Tarone CEO
At a Glance
Status: SME, Laboratory
Date of foundation: 2005
The innovative strategy of Target Heart Biotec is based on the discovery of Melusin, a muscle specific protein, with key function in triggering increased muscular power (compensatory cardiac hypertrophy) when heart is subjected to exceptional work load. This project stems from the research work developed in the past years at the Department of Genetics, Biology and Biochemistry of the University of Torino in collaboration with the Department of Experimental Medicine of the University of Rome "La Sapienza" in which it has been demonstrated that increasing melusin levels in the heart by transgene expression, leads to the activation of a compensatory hypertrophy program and prevents heart failure (Brancaccio et al. Nat. Med. 2003; 9:68-75; De Acetis et al. Circ. Res. 2005; 96:1087-94). An International patent has been deposited covering the ability of Melusin to prevent heart failure in pre-clinical animal models.
The goals of the Target Heart research project are to develop a recombinant form of melusin capable to penetrate inside the cells and induce an hypertrophy response in cardiomyocytes, both in vitro and in vivo in pre-clinical animal model of heart failure.
LICENSES/TRADE MARKS/QUALITY CERTIFICATIONS/PATENTS: Melusin, a Muscle Specific Protein, as a Drug Target for Prevention and Treatment of Heart Failure.
R&D CAPACITY: Recombinant protein generation, production and purification, antibody development, in vitro and in vivo gene transfer and expression, evaluation of cardiac function in preclinical models.
EXPERTISE: In vitro cell culture, Protein purification, western blotting, gene cloning, gene expression.
-Drug delivery&Medical services
Type of Cooperation
-DEVELOPMENT OF NEW PROJECTS
-TECHNOLOGY TRANSFER OR PRODUCTION LICENSE
-IDENTIFICATION OF NEW CUSTOMERS
-DEVELOPMENT OF NEW PRODUCTS